Macromolecular diffusion in crowded solutions

Myoglobin in crowded solutions: structure and diffusion

We present a neutron scattering study of the structure and diffusion of myoglobin solutions at high concentration. The protein–protein structure factor was determined by small angle neutron scattering (SANS) measurements using mean spherical analysis (MSA), and the intermediate scattering function was measured by neutron spin-scho spectroscopy. We observe the cross-over between self-diffusion a...

Protein diffusion in crowded electrolyte solutions.

We report on a combined cold neutron backscattering and spin-echo study of the short-range and long-range nanosecond diffusion of the model globular protein bovine serum albumin (BSA) in aqueous solution as a function of protein concentration and NaCl salt concentration. Complementary small angle X-ray scattering data are used to obtain information on the correlations of the proteins in solutio...

Diffusion in macromolecular crowded media . Monte Carlo simulation of obstructed diffusion vs . FRAP experiments

Diffusion and dynamics of γ-globulin in crowded aqueous solutions.

Dynamics in protein solutions is essential for both protein function and cellular processes. The hierarchical complexity of global protein diffusion, side-chain diffusion, and microscopic motions of chemical groups renders a complete understanding challenging. We present results from quasi-elastic neutron scattering on protein solutions of γ-globulin over a wide range of volume fractions. Trans...

Diffusion in a crowded environment.

We analyze a pair of diffusion equations which are derived in the infinite system-size limit from a microscopic, individual based, stochastic model. Deviations from the conventional Fickian picture are found which ultimately relate to the depletion of resources on which the particles rely. The macroscopic equations are studied both analytically and numerically, and are shown to yield anomalous ...